1,2 Cardiac involvement is the most serious complication, but treatment with intravenous γ-globulin (IVGG) can reduce the incidence of coronary artery abnormalities from 20% to less than 5%. The original name was quite descriptive because the disease is characterized by the typical changes in the mucous membranes that line the lips and mouth and by the enlarged and tender lymph nodes. Measles 6. DOI: 10.1161/CIR.0000000000000484 April 25, 2017 follow-up, with recurrences occurring at a median of 1.5 Given the possibility of neurological impairment owing to GS, it is important to understand the disease profile in KD. Prolonged fever for at least 5 days and presence of at least four in five main clinical criteria are required for KD diagnosis. 1 Introduction. We have experienced 540 cases with Kawasaki disease over the past 10 years. Diagnosis erythema of the lips or oral cavity or cracking of the lips rash on the trunk swelling or erythema of the hands or feet red eyes (conjunctival injection) swollen lymph node in the neck of at least 15 mm gastrointestinal complications; eye changes; neurological complications; death; Diagnosis Diagnosis of Kawasaki disease is based on the child's symptoms and how they progress. We aimed to systematically describe the general manifestations of neurological involvement in KD, determine whether neurological involvement is a marker of disease … Facial nerve paralysis (FNP) associated with KD was first reported by Murayama in 1974. Diagnosis, Treatment, and Management of Kawasaki Disease e929 CIICA TATMT AD IDI Circulation. Stevens-Johnson syndrome, a disorder of the mucous membranes 4. Kawasaki disease, sometimes called Kawasaki syndrome, is a serious inflammation of the blood vessels which affects young children, often under 5 years of age. Nervous system complications previously reported include seizure, facial nerve palsy, meningoencephalitis, hemiplegia, ataxia, chorea, ischemia, abnormal vision, disturbed consciousness, behavioral changes, sensorineural hearing loss, and monocyte-predominant pleocytosis in CSF [ 6 , 7 ]. Six of them (1.1%) had neurological complications with clinical manifestation. In the early stage, Kawasaki disease is often manifested by uncommon symptoms, such as pyuria, meningitis, shock, and retropharyngeal or parapharyngeal abscess, which may delay diagnosis and treatment. Neurologic complications, which include facial nerve palsy, seizures, and ataxia cerebral infarctions, are rare. Two infants had central nervous system involvement with remarkable changes of cerebrum on CT scan during an acute stage, and these findings disappeared completely within six months. Six of them (1.1%) had neurological complications with clinical manifestation. All patients recovered without neurological complications. Severe forms with multi‐organ involvement or neurological dysfunction are rare. Kawasaki disease mainly affects children aged 6 months to 4 years and has surpassed acute rheumatic fever as the most common cause of paediatric acquired heart disease in the industrialised world, causing cardiac complications in up to 25% of untreated individuals. The incidence of encephalopathy / encephalitis as a complication of Kawasaki disease (KD) is 0.09%, according to the 21st nationwide survey (2009–2010) of KD in Japan. Kawasaki disease (KD), as a multisystem vasculitic disorder, was first described by Kawasaki, in which coronary artery lesion is the most important complication. However, complications such as coronary artery aneurysms, depressed myocardial contractility and heart failure, myocardial infarction, arrhythmias, and peripheral arterial occlusion may develop and lead to significant morbidity and mortality (table 1). Toxic shock syndrome 5. Scarlet fever, which is caused by streptococcal bacteria and results in fever, rash, chills and sore throat 2. Two infants had central nervous system involvement with remarkable changes of cerebrum on CT scan during an acute stage, and these findings disappeared completely within six months. Kawasaki disease is an acute vasculitis, that has a classic complication of acquired coronary artery aneurysm. Acutely, the symptoms of Kawasaki disease include high fever, rash, redness of the eyes, swollen lymph nodes in the neck area, red palms and soles, swelling of the hands and feet, and tachycardia(rapid heart rate) that is out of proportion to the degree of fever. In our patients with Kawasaki disease, aseptic meningitis induced by IVIG occurred within 48 hours after initiation of IVIG, resolved within a few days, and resulted in no neurological complications, even in patients who did not receive medical treatment. Diagnosis largely is a process of ruling out diseases that cause similar signs and symptoms, including: 1. It primarily affects children age 5 or younger. Long Term Effects of Kawasaki Disease Page Content New information has led us to believe that for a subset of patients who had some abnormalities of the echocardiogram in childhood, there can be cardiovascular complications years after the acute phase of illness as a result of inflammation and scarring of the heart and blood vessels. With prompt treatment, most children with Kawasaki disease make a full recovery. Background: Kawasaki disease (KD) is an acute, self-limiting systemic vasculitis that predominately affects children. As the symptoms can be similar to other conditions it is important to exclude any other conditions. 2017;135:e927–e999. 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